Trail Blazers vs. Spurs Game 2 Predictions, Odds & Stats – April 21

Sacramento Kings v San Antonio Spurs

Photo: Ronald Cortes / Getty Images Sport / Getty Images

The San Antonio Spurs are massive 11.5-point favorites for Game 2 of the opening round of the NBA Playoffs against the Portland Trail Blazers at Frost Bank Center on Tuesday, starting at 8 p.m. ET on NBC/Peacock. The Spurs have a 1-0 series lead.

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Trail Blazers vs. Spurs Predictions for Tuesday

Our computer projections model for this encounter predicts a final result of Spurs 122, Trail Blazers 109.

  • Moneyline Pick: Spurs (-671)
  • Total Pick: Over 220.5 (computer predicts 231.0 points)
  • Pick ATS: Spurs (-11.5)

Recent Trail Blazers vs. Spurs Matchups

Spurs vs Trail Blazers (Recent Matchups)
Date Favorite Spread Total Favorite Moneyline Underdog Moneyline Result
4/19/2026 Spurs -12.5 222.5 -746 +523 111-98 SA
4/8/2026 Spurs -3.5 229.5 -168 +141 112-101 SA
1/3/2026 Spurs -8.5 236.5 -325 +260 115-110 POR
11/26/2025 Trail Blazers -1.5 240.5 -112 -107 115-102 SA
4/6/2025 Trail Blazers -3.5 225.5 -162 +136 120-109 POR
12/21/2024 Spurs -6.5 225.5 -270 +219 114-94 SA
12/13/2024 Spurs -3.5 226 -168 +141 118-116 SA
11/7/2024 Spurs -4 217.5 -173 +145 118-105 SA

Spurs 2025-26 Betting Trends

  • San Antonio is 45-35-2 ATS this season.
  • In games they have played as at least 11.5-point favorites this season, the Spurs are 8-8 against the spread.
  • A total of 35 of San Antonio's 82 games with a set total have hit the over (42.7%).
  • The Spurs have entered the game as favorites 63 times this season and won 49, or 77.8%, of those games.
  • San Antonio has a record of 12-1, a 92.3% win rate, when it's favored by -671 or more by oddsmakers this season.

Trail Blazers 2025-26 Betting Trends

  • Portland is 44-38-0 against the spread this year.
  • The Trail Blazers have a 2-2 record against the spread in games they were an underdog by 11.5 points or more this season.
  • The teams have combined to hit the over in 41 of Portland's 82 games with a set total.
  • The Trail Blazers have won 31.1% of the games this season they were the underdog on the moneyline (14-31).
  • Portland has not yet won a game when they entered play as a moneyline underdog with odds of +487 or longer in two chances.

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Trail Blazers vs. Spurs Injury Report

Spurs

Spurs:

David Jones: Out For Season (Ankle),

Jordan McLaughlin: Out (Ankle)

Trail Blazers

Trail Blazers:

Damian Lillard: Out For Season (Achilles)

Trail Blazers vs. Spurs Game Time and TV Channel

  • Game day: Tuesday, April 21, 2026
  • Game time: 8 p.m. ET
  • TV channel: NBC/Peacock
  • Location: San Antonio, Texas
  • Arena: Frost Bank Center

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